Materials And Methods
This prospective study was performed Department of Ophthalmology, Faculty of Medicine, Ahi Evran University, Kirsehir, Turkey. Patients diagnosed with nodularacne,whom
were using systemic isotretinoin (1mg/kg/day) were referred to the dermatology clinic. Informed consent forms were signed by all patients. Following the description of the Helsinki Declaration, the approval of the ethics committee was obtained. All patients underwent a complete ophthalmic examination, including best visual acuity and intraocular pressure measurements as well as biomicroscopy and fundoscopy examinations. Patients with over ± 3 diopters of refractive error, glaucoma, previous eye surgery, optic nerve diseases, macular disease and systemic diseases such as diabetes and hypertension were excluded from the study. The macular ganglion cell layer, retinal nervefiber
layer thickness, and subfoveal macular thickness were measured withHeildelberg
OCT. The macular ganglion cell layer was measured at the thickest part of the macula, whereas the retinal nervefiber
layer thickness was measured from the temporal peripapillary area.
The statistical analysiswere
performed using the Statistical Package for the Social Sciences (SPSS) software version 23.0. The variables were investigated using visual (histograms, probability plots) and analytical methods (Kolmogorov-Smirnov / Shapiro-Wilk test) to determine whether or not they are normally distributed. Descriptive analysis was presented using means and standard deviations for normally distributed variables. The t-test was used to compare parametersbetweenthe
two groups. In cases where the age and the period ofdru
normally distributed, the Mann-Whitney U test was used. While investigating the association between non-normally distributed variables, the correlation coefficients and their significance were calculated using the Spearman test. A p-value of less than 0.05 was considered to show a statistically significant result.
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