Drug development is the multistage process by which a candidate molecule is taken from initial discovery through evaluation to an approved medicine. It begins with target identification and validation, lead discovery and optimisation, and assessment of pharmacology, pharmacokinetics, and toxicology, followed by prec…
Drug development is the multistage process by which a candidate molecule is taken from initial discovery through evaluation to an approved medicine. It begins with target identification and validation, lead discovery and optimisation, and assessment of pharmacology, pharmacokinetics, and toxicology, followed by preclinical testing in cellular and animal models and, on regulatory authorisation, sequential phases of clinical trials evaluating safety, dosing, and efficacy before approval and post-marketing surveillance. The pipeline is lengthy, costly, and marked by high attrition, prompting interest in computational design, high-throughput screening, in vitro disease models, induced pluripotent stem-cell systems, and new-approach methodologies intended to improve predictivity and reduce reliance on animal testing. Structure-activity relationships, safety and cardiotoxicity assessment, and biomarker-guided and personalised strategies are central concerns, as are antimicrobial stewardship and the rapid development of vaccines. Research published in this area by the journal addresses these themes, including in silico, in vitro, and in vivo drug-design progress, high-throughput disease modelling for ethical drug discovery and cancer-biomarker development, in vitro models in preclinical cardiotoxicity and safety testing, calcium-transient assays with stem-cell-derived cardiomyocytes for compound screening, toxicology and drug-safety review, proteomic and genomic techniques in personalised medicine, antimicrobial stewardship, and COVID-19 vaccine development. These contributions span discovery, preclinical modelling, safety assessment, and translational strategy in the creation of new therapeutics.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Drug Development, linking to each citing work.