The authors have declared that no competing interests exist.
Temporal lobe meningoencephalocele is an uncommon anomaly in the face. As brain tissue herniate through the dural imperfection, cerebrospinal fluid (CSF) or a mass will appear in the mastoid, middle ear or the both. Here we present a 10 years old boy with right lobe temporal meningoencephalocele which results in CSF leakage and manifested with bacterial meningitis. He had a history of head trauma and bone fracture 3 years ago. In surgery the defect repaired and the patient showed improvement.
Meningitis is an inflammation of the brain membranes and spinal cord. Bacterial meningitis etiology has been changed in recent decade due to H. Influenza (HIB), S. pneumonia and Meningococcal vaccination
An encephalocele is a rare congenital neural tube defect. It happens when brain tissues protrude through a hole in the skull. Temporal bone encephaloceles manifest either as a mass or cerebrospinal fluid (CSF) in the middle ear or mastoid or both. Temporal lobe encephalocele is a rare disease. It is estimated about 1/3000 to 1/35000
A 10 years old boy was refered to Rasul Akram Hospital (tertiary hospital) in Tehran, Iran . The clinical presentation was headache, vertigo, and intermediate coughs for one week. The frontal and bitemporal headache intensified by head bending, just one-time fever before admission. He received Co-amoxicalve and diphenhydramine in out-patient. There wasn’t any pain relief by using the drugs and due to the headache worsening and vomiting he was taken to the clinic for serum therapy. His drug was changed to azithromycin. The day after serum therapy he had delirium and gradually leads to loss of consciousness (LOC), was intubated in first hospital, then referred and admitted in PICU of Rasool Akram hospital. In the admission day, he had a fever (39/1), pulse rate=114, respiratory rate=17, blood pressure=116/76. Pupils were in normal size and had reaction to light and his deep tendon reflexes (DTR) were decreased, no kerning or Brudzinski sign. Course crackles in both lungs and downward Babinski reflexes were found in his examination. He was self-extubated about four hours after admission to PICU and was oxygenated by nasal cannula without any decrease in O2 saturation.
Three years ago, he had a severe head trauma and skull fracture during car accident and was in coma for 3 months. He gradually improved better and could walk and speak after speech therapy, physiotherapy and occupational therapy.
Aspiration pneumonia had found in chest CT scan. In addition to blood culture and other laboratory tests, Lumbar puncture had done (without any contraindication in brain Ct scan) CSF analysis determined bacterial meningitis. All the serial laboratory tests showed in
WBC | 25800 | Neut:86% | Lym:14% | ||||
7880 | Neut:57% | Lym:31% | |||||
6100 | |||||||
6100 | 37% | 43% | |||||
RBC | 4/14 | 4/83 | 4/5 | ||||
Hb | 12 | 13/9 | 13 | 12/7 | |||
Hct | 35/5 | 38 | 39 | ||||
MCV | 29 | 80 | 86 | ||||
MCHC | 33 | 35 | 33 | ||||
Plt | 226000 | 280000 | 405000 | 253000 | |||
ESR | 31 | 74 | 59 | ||||
CRP | >48 | >48 | 12 | ||||
BS | 77 | 82 | |||||
Na | 136 | 142 | 147 | ||||
K | 4/8 | 4/4 | 3 | ||||
Ca | 11/3 | 10/9 | 10/6 | ||||
P | 2/7 | 4/6 | 4/5 | ||||
Mg | 2/7 | 2/2 | 1/7 | ||||
AST | 9 | ||||||
ALT | 19 | ||||||
ALK | 375 | ||||||
BUN | 9 | 14 | 8 | ||||
Cr | 0/7 | 0/8 | 0/8 | ||||
CPK | 985 | ||||||
LDH | 1151 | 519 | |||||
FERRITIN | 142 | 122 | |||||
LP | Wbc:6400 | Rbc:1260 | GLU:55 | Pro:210 | LDH:240 | Neut:90% | Lym:10% |
10 | 10 | 53 | 13 | 42 | 10% | ||
CSF/C | negative | Negative | |||||
U/A | SG:1017 | WBC:10 | RBC:30 | Pro:+1 | Blood:+4 | Bacteria: moderate | |
SG:1030 | WBC:1-2 | RBC:0-1 | Pro:- | Blood:- | |||
U/C | negative | Negative | |||||
B/C | |||||||
PT | 14/6 | ||||||
PTT | 29 | ||||||
INR | ½ | ||||||
D-dimer | 1317 | ||||||
ABG | PH:7/38 | PCO2:44 | PO2:27 | HCO3:26 | BE:1/2 | ||
Covid-19 | PCR | IgM:0/63 | IgG:10/33 |
Abbreviations
WBC: White Blood Cell / RBC: Red Blood Cell / Neut: Neutrophil / Lym: lymphocyte / Hb: Hemoglobin / Hct: Hematocrit / MCV: Mean Corpuscular Volume / MCHC: Mean Corpuscular hemoglobin concentration / Plt: Platelet / ESR: erythrocyte sedimentation rate / CRP: C-reactive protein / BS: Blood Sugar / Na: Sodium / K: Potassium / Ca: Calcium / P: phosphor / Mg: Magnesium / AST: Aspartate Transaminase / ALT: Alanine Transaminase / ALK: Anaplastic lymphoma kinase / BUN: Blood urea nitrogen / Cr: Creatinine / CPK: Creatine phosphokinase / LDH: Lactate dehydrogenase / Ferritin: Ferritin / LP: Lumbar puncture / CSF/C: Cerebrospinal Fluid/Culture / U/A: Urine Analysis / B/C: Blood culture / PT: Prothrombin time / PTT: Partial thromboplastin time / INR: International Normalize Ratio / D-dimer: a fibrin degradation product / ABG: Arterial Blood Gas / COVID-19: Coronavirus Disease-2019
High dose of Cefotriaxone (100 mg/kg/day) and vancomycin (20mg/kg/q6h) were started. Dexamethasone (0.6 mg/kg/day), Phenytoin (5mg/kg/day/BD), Acyclovir (10mg/kg/dose/TDS) and pneumococcal vaccine, were added. He was clearly alert at second day of admission, and he was transferred to the pediatric ward at third day. His abdominal Sonography was normal. A fracture on the right roof of the right tympan and soft tissue density in the middle ear suggestive cholesteatoma reported in Brain Ct scan on day of admission (
Despite the abnormal manifestation in mastoid cells, the audiometric examination was normal. Due to continuing the headache and right ear, the spiral HRCT of temporal bone without injection was requested. (
After ten days of treatment, lumbar puncture (LP) was done again which was absolutely normal and his headache relieved more than before. He was discharged, for further visit by ENT and neurosurgeon. Subsequently, after 2 weeks he was admitted by ENT service and was operated. That was an interesting result which was meningoencephalocele of right temporal lobe with CSF leak as detailed below.
ENT surgeon reported: A craniotomy opening is made in the squamous portion of the temporal bone and is approximately 5 cm by 5 cm. This bone flap is based on the root of the zygoma with care to avoid laceration of the underlying dura. The dura is elevated from the floor of the middle fossa. Venous bleeding was controlled with absorbable knitted fabric (Surgical) Dissection of the dura proceeds in a posterior-to-anterior manner. When the dura has been elevated with blunt Dural elevator, the House-Urban retractor was placed on the edge of a bone. The location of the bone defect was observed in anterior medial tegment tympani. The part of the brain tissue that was inside the middle ear was removed. To repair the defect, first a layer of fascia and then a piece of bone was placed on the fascia. Due to the presence of CSF leakage, another layer of fascia was extradural placed on the site of perforation and fixed on the perforated area with the help of fibrin glue. The field is inspected for hemostasis, and the middle fossa retractor is removed, the bony flap was fixed in place by suturing it to the surrounding bones. A mastoid dressing completes the closure.
Our case was visited 2 and 6 months after his surgery without any complications and he had normal hearing.
An encephalocele usually happens when brain tissue herniates through a dural defect of the skull. Temporal bone encephaloceles show either as a mass or cerebrospinal fluid (CSF) in the middle ear or mastoid or both.
Cerebrospinal fluid otorrhea and temporal lobe encephaloceles (TLEs) including the tegmen tympani also mastoide are infrequent. neurotologic conditions that have become more common in the past 10 years.
Cerebrospinal fluid otorrhea and TLE come with serious aftermaths such as meningitis and brain abscesses, including conductive hearing loss and chronic middle ear effusion.
All temporal bone CSF usually occur through the tegmen (tympani or mastoideum) and through the temporal lobe dura. Posterior fossa plate that leak over the cerebellum are not common.
CSF leaks that are secondary to head trauma are well documented. It usually resolves spontaneously or with lumbar drainage within 1 to 2 weeks after the incident.
Usually, Preparatory radiographic evaluation begins with a high-resolution computed tomography (CT) of the skull base. A magnetic resonance imaging (MRI) study is helpful to display for the presence of an encephalocele and may confirm that the effusion has a similar signal characteristic as CSF. If CT and MRI are non-diagnostic, other imaging formats such as a radionucleotide cisternogram study could be helpful.
A more frequent discovery is a soft compressible mass in the mastoid cavity comming off the tegment that may mimic a blue dome cyst or cholesterol granuloma.
MRI is the gold standard technique for detecting brain tissue herniation in middle ear cavities. The involved tissue is shown as a mass iso-intense in all sequences in MRI. Hypo intense in T1 and hyper intense in T2 with diffusion weighted sequences
CT scan is the other technique for diagnosis. It is so much important to detect the size and location of the involved bones with high resolution computer tomography; but there is a defect with that which cannot detect the solidarity of soft tissues. It has limitation in detecting granulation, cholesteatoma, cholesterol granuloma or other soft tissue masses inside the middle ear cavity.
Different surgical techniques now are available. Repairing the whole layers (bone and soft tissue) is more effective than the only repair in soft tissue, due the increased risk of recurrence
Middle cranial fossa craniotomy (MCF), trans mastoid and combined MCF/trans mastoid are one of the surgical techniques for temporal bone CSF-L which reduces the risk of meningitis, conductive hearing loss and otorrhea
CSF: Cerebrospinal Fluid
HIB: Hemophilus Influenza
PICU: Pediatric Intensive Care Unit
DTR: Deep Tendon Reflexes
LP: Lumbar Puncture
MRI: Magnetic Resonance Imaging
HRCT: High Resolution Compound Tomography
ENT: Otorhinolaryngology
GCS: Glasgow Coma Score
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