Research Topic · Peer-Reviewed

Cancer Stem Cells

Cancer stem cells (CSCs) are a small subpopulation of tumor cells that possess the capacity for self-renewal and for differentiating into the diverse cell types that make up a tumor, and they are thought to drive tumor initiation, growth, metastasis, and recurrence. The concept proposes that tumors are hierarchicall…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 30× across the literature 🔖 ISSN 2574-4372 🗓 Reviewed July 2026

Overview

Cancer stem cells (CSCs) are a small subpopulation of tumor cells that possess the capacity for self-renewal and for differentiating into the diverse cell types that make up a tumor, and they are thought to drive tumor initiation, growth, metastasis, and recurrence. The concept proposes that tumors are hierarchically organized, with CSCs sitting at the apex and sustaining the malignancy much as normal stem cells maintain healthy tissues. Because CSCs are frequently more resistant to conventional chemotherapy and radiotherapy, their persistence is implicated in treatment failure and relapse, making them an important target for therapies aimed at eradicating the cells that regenerate cancer. Research in this journal investigates the biology of cancer stem cells and related stem-cell processes, including the evaluation of circadian oscillators in cancer stem cells and the question of whether CSCs are a cause or a consequence of field cancerization. Adjacent studies in the broader stem-cell and cancer-biology literature address regulation of pluripotency genes such as OCT4, molecular and cellular events in the initiation of sporadic solid cancers, epigenetic biomarkers in head and neck cancer, and the wider landscape of stem-cell therapies and regenerative medicine. Ongoing work seeks reliable markers to identify CSCs, an understanding of their resistance mechanisms, and strategies to selectively target them.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Evaluating Circadian Oscillators in Cancer Stem Cells

E. Geusz MichaelCorresponding author
Bowling Green State University, Dept. of Biological Sciences, Bowling Green, OH 43403
Exact topic Evolving Stem Cell Research Cited by 1 doi:10.14302/issn.2574-4372.jesr-14-607
2018

Epigenetic Biomarkers in Head and Neck Cancer 

Gupta ShilpiCorresponding author
Stem Cell and Cancer Research Lab, Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sector-125, Noida-201313, India.
Exact topic Cancer Genetics And Biomarkers Cited by 11 doi:10.14302/issn.2572-3030.jcgb-18-2428

How this research is being cited

The 12 articles above have been cited 30 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Cancer Stem Cells, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Evolving Stem Cell Research (ISSN 2574-4372).

Journal editorial board
Takafumi Yokota · Japan Chiara Raggi · Italy Morikuni Tobita · Japan

This page summarises published research for orientation; it is not medical or professional advice.