Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, arising from the transformation of hepatocytes, the liver's principal functional cells. It typically develops on a background of chronic liver injury and cirrhosis and is a leading cause of cancer-related death worldwide. The major ri…
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, arising from the transformation of hepatocytes, the liver's principal functional cells. It typically develops on a background of chronic liver injury and cirrhosis and is a leading cause of cancer-related death worldwide. The major risk factors for HCC include chronic hepatitis B and C virus infection, alcohol-related liver disease, non-alcoholic fatty liver disease, and exposure to carcinogens such as aflatoxins, most of which act by driving long-standing inflammation, fibrosis, and cirrhosis. Tumor development involves progressive genetic and epigenetic changes, dysregulated signaling, and pronounced angiogenesis that supports tumor growth. Diagnosis combines imaging, serum biomarkers such as alpha-fetoprotein, and, when needed, biopsy, while treatment ranges from surgical resection and liver transplantation to local ablation, transarterial therapies, and systemic agents, with prognosis depending heavily on stage and underlying liver function. Research grouped under this topic addresses several of these dimensions, including angiogenic markers in HCC complicating hepatitis C, alpha-fetoprotein and its receptor as oncofoetal antigens, transcription-factor and signaling analyses relevant to cancer, hospital-based studies of liver disease, and immunoassay and immunogenomic approaches for monitoring cancer, reflecting both the clinical and molecular study of this liver cancer.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Hepatocellular Carcinoma, linking to each citing work.