Research Topic · Peer-Reviewed

Chronic Heart Failure

Chronic heart failure is a progressive clinical syndrome in which the heart cannot pump blood at a rate sufficient to meet the metabolic demands of the body, or can do so only at elevated filling pressures. It arises from conditions that impair the myocardium, including ischaemic heart disease, hypertension, valvula…

Curated from this journal's research 📚 9 peer-reviewed articles cited Cited 12× across the literature 🗓 Reviewed July 2026

Overview

Chronic heart failure is a progressive clinical syndrome in which the heart cannot pump blood at a rate sufficient to meet the metabolic demands of the body, or can do so only at elevated filling pressures. It arises from conditions that impair the myocardium, including ischaemic heart disease, hypertension, valvular disease, and cardiomyopathy, and is classified by left-ventricular ejection fraction into reduced, mildly reduced, and preserved phenotypes. Neurohormonal activation of the sympathetic nervous system and the renin-angiotensin-aldosterone axis drives fluid retention, vascular constriction, and adverse cardiac remodelling, producing the characteristic dyspnoea, fatigue, and peripheral oedema and a course marked by progression and recurrent decompensation. Research in this area examines cardiorenal signalling pathways that link cardiac and kidney dysfunction, and the prognostic value of N-terminal pro-B-type natriuretic peptide in predicting cardiac morbidity and mortality. Other work surveys gene therapy as an emerging treatment strategy for heart failure and assesses cardiac function and sleep-disordered breathing through ambulatory acoustic cardiography. Studies of heart-rate variability, percutaneous coronary intervention in ischaemic heart disease, and breathing-based interventions reflect the autonomic, ischaemic, and rehabilitative dimensions of the syndrome. Collectively the field addresses the mechanisms, biomarkers, monitoring, and evolving therapies that govern the diagnosis and long-term management of chronic heart failure.

Research published in this journal

9 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 9 articles above have been cited 12 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Chronic Heart Failure, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Heart Research.

Journal editorial board
Mario Giovanni Gerardo D'Oria · Italy

This page summarises published research for orientation; it is not medical or professional advice.