Alzheimer's Disease

Overview

Alzheimer's disease is a progressive neurodegenerative disorder and the most common cause of dementia, characterized neuropathologically by extracellular amyloid-beta plaques, intracellular neurofibrillary tangles of hyperphosphorylated tau, synaptic loss, and cortical and hippocampal atrophy that manifest clinically as deteriorating memory, executive function, language, and behavior. Disease processes begin years before symptom onset, motivating intensive work on early detection, fluid and imaging biomarkers, genetic risk modifiers, and both pharmacological and non-pharmacological management. Research in this area examines molecular and circulating biomarkers including circular RNAs and plasma TREM2 levels modulated by MS4A6A polymorphism, retinal optical coherence tomography as a non-invasive technique for early prediction, and the relationship between basal serum cortisol, depression, and medial temporal lobe atrophy across mild cognitive impairment and established disease. Further work distinguishes the neurobiology of aggression from agitation in dementia and evaluates non-pharmacological interventions for disrupted sleep in moderate-to-severe populations through systematic review, while caregiver-focused studies separate genuine knowledge gaps from entrenched misconceptions. Therapeutic exploration extends to neuromodulatory approaches such as vagus nerve stimulation. The journal publishes peer-reviewed research spanning these biomarker, imaging, genetic, behavioral, and care-delivery dimensions, reflecting the multidisciplinary effort to diagnose, slow, and manage Alzheimer's disease and related dementias.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 33 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Biodynamic lighting versus bright light effects on rest-activity rhythm and night-time sleep in nursing homes residents with dementia
  2026 · BMC Geriatrics
• Peripheral biomarkers of neuroinflammation in Alzheimer’s disease and vascular dementia
  2026 · Biochemical Pharmacology
• Association of peripheral blood NLRP3, sTREM2, and p-tau217 levels with cognitive outcomes in patients with chronic alcohol-related brain damage
  2026 · Alcohol and Alcoholism
• Agitation in dementia and music therapy: A theoretical study of the legitimacy of reductionist music-based interventions
  2026 · Nordic Journal of Music Therapy
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  Hami Hemati et al. · 2025 · Brain, behavior, and immunity
• Apolipoprotein E (APOE) Isoforms, Neuropsychiatric Symptoms, and Sporadic Alzheimer’s Disease
  2025 ·
• Knowledge and Attitude of Filipino Caregivers of Patients with Dementia Admitted for other Health Issues in a Tertiary Hospital in Metro Manila: A Descriptive Cross-sectional Study
  Raymond U. Tan et al. · 2025 · Acta medica Philippina
• Chronic alcohol consumption induces phenotypic and functional alterations consistent with a hyper-inflammatory state in peripheral blood mononuclear cell-derived microglia in a rhesus macaque model
  2025 · Brain Behavior and Immunity

A sample of recent works citing this journal's research on Alzheimer's Disease, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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