Research Topic · Peer-Reviewed

Phosphorylation

Phosphorylation is the biochemical transfer of a phosphate group, most commonly from ATP, to an acceptor molecule such as a protein, lipid, sugar, or nucleotide. Protein phosphorylation, catalysed by kinases and reversed by phosphatases, typically modifies serine, threonine, or tyrosine residues and constitutes one …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 106× across the literature 🔖 ISSN 2377-2549 🗓 Reviewed July 2026

Overview

Phosphorylation is the biochemical transfer of a phosphate group, most commonly from ATP, to an acceptor molecule such as a protein, lipid, sugar, or nucleotide. Protein phosphorylation, catalysed by kinases and reversed by phosphatases, typically modifies serine, threonine, or tyrosine residues and constitutes one of the principal post-translational mechanisms for regulating enzyme activity, protein conformation, molecular interactions, and subcellular localisation. As a rapid, reversible switch, it propagates intracellular signal-transduction cascades that govern metabolism, proliferation, differentiation, apoptosis, and synaptic plasticity. Kinase signalling participates in developmental pathways such as Wnt-dependent oligodendrocyte maturation and in inflammatory control through factors regulated downstream of NF-κB, while dysregulated phosphorylation and aberrant kinase activity are central to cancer biology, including cyclin-dependent kinase signalling and the search for kinase inhibitors. Phosphorylation-linked mechanisms also feature in endocrine and metabolic regulation, in interferon and cytokine signalling, and in the modulation of neuronal plasticity. Oxidative phosphorylation, a distinct but related process, harnesses phosphate transfer to synthesise ATP during cellular respiration. Studies in this area dissect kinase pathways and their roles across signalling, metabolism, and disease. The journal publishes peer-reviewed research on phosphate transfer, kinase signalling, and the regulation of cellular processes by phosphorylation.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Adaptive Contribution of Thyroid Hormones in Obesity

Ozcelik FatihCorresponding author
University of Health Sciences, Faculty of Medicine, Department of Medical Biochemistry, Istanbul, Turkey
Exact topic International Journal of Negative Results Cited by 2 doi:10.14302/issn.2641-9181.ijnr-18-2530

How this research is being cited

The 12 articles above have been cited 106 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Phosphorylation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in New Developments in Chemistry (ISSN 2377-2549).

Journal editorial board
Annarita Del Gatto · Italy Bharat Gurale · United States Palani ELUMALAI · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.