Osteoporosis is a systemic skeletal disorder characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to increased bone fragility and susceptibility to low-trauma fractures, particularly of the hip, vertebrae, and wrist. It arises from an imbalance in bone remodelling, in which ost…
Osteoporosis is a systemic skeletal disorder characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to increased bone fragility and susceptibility to low-trauma fractures, particularly of the hip, vertebrae, and wrist. It arises from an imbalance in bone remodelling, in which osteoclast-mediated resorption exceeds osteoblast-mediated formation, and is strongly influenced by declining sex-steroid levels, notably the fall in oestrogen after menopause, as well as ageing, calcium and vitamin D status, and secondary causes. Bone mineral density, typically quantified by dual-energy absorptiometry, is the principal diagnostic measure, while trabecular bone structure and marginal bone loss provide further insight into skeletal integrity. Management combines adequate calcium and vitamin D intake, weight-bearing activity, fall prevention, and pharmacological agents that suppress resorption or stimulate formation. The condition intersects with falls and balance impairment in older adults, secondary hip fracture risk, and the contribution of comorbidities and medications. The peer-reviewed research gathered here addresses osteoporosis knowledge and calcium intake in women, vitamin D and bone-health biomarkers in osteoblast models, trabecular bone structure, secondary fracture risk in ageing populations, and experimental models of bone loss, reflecting both the clinical and the cellular dimensions of preventing and treating skeletal fragility.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 18 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Osteoporosis, linking to each citing work.