Insulin resistance is a state in which target tissues, principally liver, skeletal muscle, and adipose tissue, respond inadequately to insulin, so that higher hormone concentrations are required to achieve normal glucose disposal. It arises from impaired post-receptor signalling, often associated with ectopic lipid …
Insulin resistance is a state in which target tissues, principally liver, skeletal muscle, and adipose tissue, respond inadequately to insulin, so that higher hormone concentrations are required to achieve normal glucose disposal. It arises from impaired post-receptor signalling, often associated with ectopic lipid accumulation, adipose-tissue dysfunction, chronic low-grade inflammation, and excess free fatty acids, and it is compensated initially by hyperinsulinaemia until beta-cell capacity is exceeded. Insulin resistance is the pathophysiological core of type 2 diabetes and metabolic syndrome and is linked to obesity, polycystic ovary syndrome, non-alcoholic fatty liver disease, and cardiovascular risk; it is assessed through fasting indices and surrogate measures of insulin sensitivity. The peer-reviewed work assembled here engages these themes: cinnamon supplementation and insulin resistance in polycystic ovary syndrome, evaluation of surrogate indices distinguishing insulin-sensitive from insulin-resistant obese postmenopausal women, dietary approaches to reversing obesity, antioxidant micronutrients in metabolic-syndrome management, the impact of nutrients on diabetes, the physiology of adipose tissue in obesity, and the effects of exercise on irisin in obese women. Across these studies insulin resistance appears through its association with obesity, adipose-tissue physiology, metabolic syndrome, and reproductive endocrine disorders, and through nutritional and lifestyle interventions. The collection situates insulin resistance as a central mechanism linking adiposity to metabolic and hepatic disease, and a target for dietary, exercise, and pharmacological intervention.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 23 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Insulin Resistance, linking to each citing work.