Overview
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, originating in hepatocytes, the main functional cells of the liver. It most often affects middle-aged and older adults and is commonly associated with risk factors such as chronic hepatitis B and C virus infection, heavy alcohol consumption, smoking, obesity, and dietary exposure to aflatoxins. Because the disease often presents late and carries a serious prognosis, early diagnosis and treatment are central to improving survival, and much research focuses on the underlying biology and on markers that aid detection. Articles in this journal explore hepatocellular carcinoma and related liver disease from biological and clinical perspectives. Studies examine angiogenic markers including Tie2, CD14, and angiopoietin in HCC complicating hepatitis C, the role of alpha-fetoprotein and its receptor as oncofetal antigens, and a case of central retinal vein occlusion in the context of HCC. Additional contributions consider trends in chronic liver disease through hospital-based studies, the reduction of aflatoxicosis in experimental animals, and molecular and immunogenomic approaches to cancer and infectious disease. Together these works present hepatocellular carcinoma as a subject spanning hepatology, oncology, virology, and experimental and comparative biology.
Research published in this journal
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
Role of Tie2, CD14, Angiopoietin as Angiogenetic Markers in Hepatocellular Carcinoma Complicating Hepatitis C Virus Infection
Computational STAT4 rSNP Analysis, Transcriptional Factor Binding Sites and Disease
The Assessment of Alchornea Cordifolia Activity in Aflatoxicosis Reduction in Rat.
Liver Disease: A Retrospective Hospital Based Study in Addis Ababa-Ethiopia
Epigenetics and Nutrition
Rbm45 Phylogenetics, Protein Domain Conservation, and Gene Architecture in Clade Metazoa
Magnitude and Trends of Chronic Liver Disease: A Retrospective Hospital Based Study in Eastern Amhara Region, Northeast Ethiopia
Thyroid Transcription Factor-1 Activity is Required for the Proliferation of Human Thyroid Cancer Cells 8505C
Alpha-Fetoprotein and its Receptor: More Than Oncofoetal Antigens.
RBM45: Molecular, Cellular, and Evolutionary Biology
The Current Immunoassays and Emerging Immunogenomic Approaches for Immunomonitoring Cancer and Infectious Diseases
How this research is being cited
The 12 articles above have been cited 42 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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2026 · BioMed Research International
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2025 · BMC Genomics
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2025 · BMC Gastroenterology
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2025 · BMC Gastroenterology
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2025 · Journal of Liver Cancer
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2024 · Risk Management and Healthcare Policy
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2024 · Journal of Environmental Pathology, Toxicology and Oncology
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2024 · Risk Management and Healthcare Policy
A sample of recent works citing this journal's research on Hepatocellular Carcinoma, linking to each citing work.