Journal of Neurological Research And Therapy
- Motor neuron dysfunction
- ETC-complexes dysregulation
- Energy failure
- Cognitive and behavioral alterations
Welcomes submissions to the thematic concept on 'Neuronal mitochondrial dysfunction in motor neuron disorders'. Motor neuron disorders (MND) that attacks myelinated neurons in specific brain regions; characterized by oligodendrocytes destruction causes demyelination, neuroinflammation, mitochondrial abnormalities, oxidative stress and neurotransmitter deficits associated with motor and cognitive dysfunctions, vertigo and muscle weakness. Limited intervention of pharmacologically active compounds used clinically are majorly associated with adverse drug reactions. Pre-clinically, neurotoxin mimics the behavioral and biochemical alterations present in MND rats associated with downregulation of mitochonrial efficiency activation further responsible for varieties of neuropathogenic factors. In spite of considerable investigate into neuroprotection, treatment choices are still constrained to strong care and organization of complications. As of now accessible drugs give symptomatic alleviation but don’t end development of illness. In this way, the advancement of unused helpful techniques remains neglected restorative requires. Disappointment of current steady treatment may be due to their activity at as it were one of numerous neurotransmitters included or their failure to up direct signaling flag bearers detailed to have vital part in neuronal sensitivity, neurotransmitter biosynthesis and discharge, neuronal development and separation, synaptic versatility and cognitive working.
Submission Instructions: All submissions will undergo peer review and accepted articles will be published in the Journal of Neurological Research And Therapy (ISSN: 2470-5020).