Special Issue On - Neuronal mitochondrial dysfunction in motor neuron disorders 

 

Special Issue By - Dr. Sidharth Mehan

 

This special issue calls for original papers with important and novel contributions related to – “Neuronal mitochondrial dysfunction in motor neuron disorders ”

 

Topics of interests include

• Motor neuron dysfunction 
• Mitochondria
• ETC-complexes dysregulation
• Energy failure
• Cognitive and behavioral alterations

Reviews which include the comparative view, Original research papers as well as short communications and letters on new developments and applications are welcome and are to be written in Standard English. Formatting of the manuscript with headings and Subheadings is necessary and views are to be presented clearly. New approaches are mainly in interest.

To cover the costs of publication, an Article Processing Charge is essential and the charge levied for each article of any type upon acceptance is $810 USD.

Metrics:

Acceptance period: 14 days from the submitted date People involved: Dr. Sidharth Mehan  - Editor

Welcomes submissions to the thematic concept on 'Neuronal mitochondrial dysfunction in motor neuron disorders'. Motor neuron disorders (MND) that attacks myelinated neurons in specific brain regions; characterized by oligodendrocytes destruction causes demyelination, neuroinflammation, mitochondrial abnormalities, oxidative stress and neurotransmitter deficits associated with motor and cognitive dysfunctions, vertigo and muscle weakness. Limited intervention of pharmacologically active compounds used clinically are majorly associated with adverse drug reactions. Pre-clinically, neurotoxin mimics the behavioral and biochemical alterations present in MND rats associated with downregulation of mitochonrial efficiency activation further responsible for varieties of neuropathogenic factors. In spite of considerable investigate into neuroprotection, treatment choices are still constrained to strong care and organization of complications. As of now accessible drugs give symptomatic alleviation but don’t end development of illness. In this way, the advancement of unused helpful techniques remains neglected restorative requires. Disappointment of current steady treatment may be due to their activity at as it were one of numerous neurotransmitters included or their failure to up direct signaling flag bearers detailed to have vital part in neuronal sensitivity, neurotransmitter biosynthesis and discharge, neuronal development and separation, synaptic versatility and cognitive working. 

Submission Instructions: All submissions will undergo peer review and accepted articles will be published in the Journal of Neurological Research And Therapy (ISSN: 2470-5020).