Journal of Preventive Medicine and Care

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Research Article Open Access
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  • Prevalence and Risk Factors of Metabolic Syndrome Among Teaching Staff of Engineering Colleges in Central India

    Sanjay Agrawal 1   Sanjeev M. Chaudhary 2   Sanjay S. Kubde 3   Manjusha Dhoble 4   Moin Shaikh 5  

    1Assistant Professor cum Statistician, Department of Community Medicine, Indira Gandhi Government Medical College, Nagpur

    2Associate Professor, Department of Community Medicine, Government Medical College, Akola.

    3Professsor, Department of Community Medicine, Government Medical College, Nagpur

    4Assistant Professor, Department of Community Medicine, Indira Gandhi Government Medical College, Nagpur

    5Medical Officer, Maharashtra Medical and Health Services

    Abstract

    Background

    Prevalence of Metabolic syndrome is high among Asians including Indians, and is high among those having sedentary occupations. Teaching is one of the important occupations, which demands no strenuous physical activity. However, there is little information available about the prevalence of metabolic syndrome among teaching staff of engineering college. Hence, the present study was conducted to study its prevalence, certain risk factors and co-morbidities among teaching staff of engineering institutes.

    Methods

    Teachers from engineering colleges of Nagpur city were the study subjects. Data was collected by interview technique. Clinical examination and laboratory investigations like Fasting blood glucose, High Density Lipoproteins and Serum Triglycerides were done. National Cholesterol Evaluation Programme (NCEP) Adult Treatment Panel Three (ATPIII) criteria were used to study Metabolic syndrome. Blood pressure and anthropometric measurements like height, weight and waist circumference were obtained by standard methods.

    Results

    The prevalence of metabolic syndrome was found to be 20.5%. It was 25.32% in females and 19.31% in males. It was more common in subjects of higher age group, muslim religion, and among widows and separated. Alcohol consumption, smoking and sedentary life style was found to be significantly associated with presence of metabolic syndrome. Frozen shoulder, fungal infection and stroke were common co morbidities found among subjects having metabolic syndrome.

    Author Contributions
    Received 21 Dec 2020; Accepted 23 Dec 2020; Published 25 Dec 2020;

    Academic Editor: Khuram SHAHZAD, Department of Polymer Engineering and Technology, University of the Punjab, Lahore, 54590 Pakistan.

    Checked for plagiarism: Yes

    Review by: Single-blind

    Copyright ©  2020 Sanjay Agrawal, et al.

    License
    Creative Commons License     This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Competing interests

    The authors have declared that no competing interests exist.

    Citation:

    Sanjay Agrawal, Sanjeev M. Chaudhary, Sanjay S. Kubde, Manjusha Dhoble, Moin Shaikh (2020) Prevalence and Risk Factors of Metabolic Syndrome Among Teaching Staff of Engineering Colleges in Central India. Journal of Preventive Medicine And Care - 3(2):8-16.

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    DOI 10.14302/issn.2474-3585.jpmc-20-3672

    Introduction

    The rapid rise of non communicable diseases (NCDs) is presenting a challenge in twenty-first century which is threatening economic and social development of the world as well as the lives and health of millions across the globe. As many countries are struggling to control infectious diseases, they are facing an explosion in chronic diseases- a situation for which they have neither the resources and personnel, nor the health service infrastructure required to respond effectively. Of the 57 million deaths that occurred globally in 2008, 36 million – almost two thirds – were due to NCDs, comprising mainly cardiovascular diseases, cancers, diabetes and chronic lung diseases. Especially in developing countries, the burden of chronic diseases is increasing rapidly and will have significant social, economic, and health consequences in the coming years.

    India is also undergoing rapid urbanization with increased industrialization, rising incomes, expanded education and improved health care. There is increase in smoking habits, an unhealthy diet, physical inactivity and adoption of other unhealthy lifestyles leading to rise in prevalence of non communicable diseases. On the other hand, modern medical care is now enabling many with chronic diseases to survive. The impact of chronic diseases on the lives of people is serious when measured in terms of years of loss of life, disablement, family hardship, poverty and economic loss to the country.

    Metabolic syndrome , which is also known as “Syndrome X,” was first described by Reaven in his 1988 Bantin Lecture1. It is characterized by clustering of cardiovascular risk factors, namely central obesity, elevated blood pressure, elevated plasma glucose, and dyslipidemia.It is increasingly attracting the attention of international research institutions and scientific societies, as a major modifiable determinant of cardiovascular disease and type 2 diabetes. There are various definitions proposed for the metabolic syndrome. National Cholesterol Education Program – Adult Treatment Panel III (NCEP-ATP III)2 and the American Heart Association (AHA)/ National Heart Lung and Blood Institute (NHLBI)3 defined the Metabolic syndrome as presence of any three out of the five components namely central obesity, raised triglycerides, low HDL, raised plasma glucose and raised blood pressure. On the other hand, the International Diabetes Federation (IDF)4 definition includes central obesity as an essential component of the Metabolic syndrome in addition to any two of the four above-mentioned components.

    Prevalence of Metabolic syndrome is high among Asians including Indians and is rising particularly with the adoption of modernized lifestyle. Many studies in India have reported high prevalence of Metabolic syndrome in a range of 9–48%.5 But there are limited data on comparison of the Metabolic syndrome criteria in the same study population to assess the strengths and limitations of the proposed criteria in the context of South Asian ethnicity. Teaching is one of the important occupations, which demands no strenuous physical activity. Teaching staff is usually sedentary. It was observed in many studies that the metabolic syndrome and cardiovascular diseases are rising in sedentary population. However, there is little information available about the prevalence of metabolic syndrome among teaching staff of engineering college. Hence, the present study was conducted to study its prevalence, certain risk factors and co-morbidities among teaching staff of engineering institutes.

    Material and Methods

    The present cross sectional study was carried out among teaching staff of engineering colleges in central part of Nagpur city. Four engineering colleges were selected randomly from the list of engineering colleges of Nagpur. Institutional ethics committee’s clearance was sought before the start of study. The necessary permission was obtained from the Principal of each engineering college for conducting the present study. Study subjects were explained regarding objective and nature of study, and their consent was sought before data collection. Members of the physical education department of engineering college co-operated in conducting the study. They made necessary arrangements to carry out the physical examination and facilitated the interviewing of study subjects.

    The list of teaching staff was obtained from college authority. A time schedule was prepared for study subjects so that they could participate in the study conveniently. All individuals who participated in this project received a verbal explanation of the procedures involved and the benefits expected from the study. All respondents were asked to sign an informed consent form prior to the commencement of the study. Anonymity of the study subjects and confidentiality of all the data was assured during the process of data collection and it was explained that all results would be reported as a group data so that no individual could be identified.

    Those study subjects who could not be examined due to absence on the day of data collection were called at Urban Health Training Centre for examination and laboratory investigations. The pilot study was done on 100 participants. The pilot study was carried out to check the feasibility and to test the proforma. Necessary changes were made in the proforma after pilot study. The pretested structured questionnaire was used for collection of data. Data was collected by interview technique. Clinical examination and necessary laboratory investigations were done. National Cholesterol Evaluation Programme (NCEP) Adult Treatment Panel Three (ATPIII) criteria were used to study Metabolic syndrome. Physical activity assessed by usingjoint FAO/WHO expert consultation, Rome, Oct.2001. Blood pressure and anthropometric measurements like height, weight and waist circumference were obtained by standard methods. After an overnight fasting, blood samples for High Density Lipoproteins and Serum Triglycerides were taken. Five milliliters of venous blood was taken from the ante- cubital fossa with all aseptic precautions and placed in empty sterile tubes. The samples were transported to the Biochemistry laboratory of the Medical College, for analysis within a day, using an automated ARCHITECT c8000 machine. Fasting blood sugar was measured by using Accu-check glucometer.

    Data Analysis

    Epi info version 7, open Epi info and Statcal were used to analyze the data. Chi square tests were used to examine differences in responses among the demographic variables, risk factors and knowledge on a number of variables.

    Sample Size

    Assuming prevalence of 0.5, confidence level of 90% and relative error of 10%, sample size (n) was estimated as n =Z2(1-α) 2×p× (1-p)/ d2=3.84×0.5×0.5/(0.05) 2=384

    A total of 152, 128, 77 and 43 teachers of the four engineering institutes were included in our study, which made the total sample of 400.

    Results

    Out of a total of 400 teachers, 321(80.25%) were males and 79 (19.75%) were females. As seen in Table 1, majority of the subjects were of over 40 years of age, maximum study subjects belonged to Hindu religion, were from nuclear family, were married and consumed a mixed diet. Around 7% subjects had diabetes mellitus, and similar number of subjects had hypertension. Maximum subjects were doing moderate physical activity. BMI of around half of the study subjects was found to be in normal range.

    Table 1. Demographic characteristics of study subjects
      Male (n=321) Female(n=79)
      No. Percent No. Percent
    Age group (years)        
    <30 6 1.87 2 2.53
    31—40 99 30.84 24 30.38
    41-50 143 44.55 31 39.24
    51-60 73 22.74 22 27.85
    Religion        
    Hindu 199 62.00 39 49.37
    Muslim 62 19.31 16 20.25
    Buddha 29 9.03 17 21.52
    Others 31 9.66 7 8.86
    Marital status        
    Married 287 89.40 70 88.60
    Unmarried 12 3.74 1 1.27
    Widowed 10 3.12 8 10.13
    Divorced 12 3.74 0 0
    Type of family        
    Nuclear 238 74.14 59 74.68
    Joint 71 21.12 14 17.72
    Three Generation 12 3.74 6 7.59
    Type of diet        
    Vegetarian 60 18.69 31 39.24
    Mixed 261 81.31 48 60.76
    History of past illness        
    DM 23 7.17 6 7.59
    HT 24 7.48 8 10.1
    MI 13 4.05 3 3.8
    Family history        
    DM 35 10.9 9 11.4
    HT 32 9.97 10 12.7
    Obesity 18 5.61 4 5.06
    MI 13 4.05 1 1.27
    Stroke 4 1.25 0 0
    Physical Activity        
    Sedentary 63 19.6 24 30.4
    Moderate 222 69.2 53 67.1
    Vigorous 36 11.2 2 2.53
    BMI        
    <18.5 (underwt.) 1 0.31 0 0
    18.5-22.9 (normal) 169 52.6 45 57
    23-27.49 (overwt.) 117 36.4 21 26.6
    ≥27.5 (obese) 34 10.6 13 16.5

    (Table 2) shows mean and standard deviation of different components of metabolic syndrome among the subjects. Except triglycerides, mean of all the parameters was more among males as compared to females, though the difference was statistically not significant. In contrast, prevalence of individual component of metabolic syndrome was higher in females, for all components except high density lipoprotein (Table 3).

    Table 2. Mean and standard deviation of individual component of metabolic syndrome
    Component of Metabolic syndrome Malen=321 Femalen =79 Total(n=400)
    Waist circumference (cm) 85.50±5.07 81.02±5.72 84.61±5.49
    Systolic BP (mmHg) 124.06±10.96 123.99±11.73 124.05±10.50
    Diastolic BP(mmHg) 83.21±50.66 80.30±5.62 82.63±45.45
    Blood glucose (mg/dl) 92.92±30.77 91.57±37.26 92.64±30.83
    Triglycerides≥150mg/dl 140.03±11.98 141.94±14.34 140.4±12.4
    High Density Lipoproteins(mg/dl) 51.43±9.20 44.81±8.16 51.12±9.3

    Mean + SD
    Table 3. Prevalence of individual component of metabolic syndrome
    Component of Metabolic syndrome Malen=321 No.(%) Femalen=79 No.(%) Totaln=400 No.(%)
    Waist circumference ≥cut off 45(14.01) 44(55.70) 89(22.25)
    Elevated blood pressure+ Known cases 71(22.11) 23(29.11) 94(23.25)
    Elevated blood glucose level + known cases 78(24.30) 25(31.64) 103(25.75)
    Triglycerides≥150 mg/dl 40(12.46) 17(21.51) 57(14.25)
    HDL≤ Cut off 76(23.67) 18(22.78) 94(23.5)

    Majority of the study subjects i.e. 41 (10.25%) were having 3 components of Metabolic Syndrome at a time, followed by 30 (7.5%) subjects who were having 4 components. Eleven subjects (2.75%) were having 5 components of Metabolic Syndrome at a time (Table 4).

    Table 4. Number of components of metabolic syndrome
    No. of componentsof Metabolic Syndrome* Male Female Total
    No. % No. % No. %
    None 226 70.40 50 63.29 276 69.00
    1 24 7.47 2 2.54 26 6.50
    2 10 3.12 6 7.59 16 4.00
    3 30 9.35 11 13.92 41 10.25
    4 23 7.17 7 8.86 30 7.50
    5 8 2.49 3 3.80 11 2.75
    Total 321 100 79 100 400 100

    Study subjects having 3 and more than 3 components of Metabolic syndrome constituted 82 (20.5%). So the prevalence of metabolic syndrome was found to be 20.5%. In present study, as seen in Table 5, metabolic syndrome was found to be significantly associated with advanced age, married status, alcohol abuse, smoking and physical inactivity.

    Table 5. Factors associated with metabolic syndrome
    Factors Metabolic syndrome Chi square value
      Present (n=82) Absent (n=318)  
    Age>40 years 69 (84.15) 200 (62.89) 13.3*
    Sex- male 61 (74.39) 260 (81.76) 2.34**
    Religion- Hindu 50 (60.98) 188 (59.12) 0.09**
    Marital status- married 66 (80.49) 291 (91.51) 8.25*
    Alcohol abuse 13 (15.85) 22 (6.92) 6.51*
    Smoking 26 (31.71) 43 (13.5) 15.1*
    Mixed Diet 67 (81.71) 242 (72.6) 1.16**
    No Physical activity 44 (53.66) 231 (72.6) 10.9*

    * df=1, p<0.05, significant
    ** df=1, p≥0.05, non significant

    Metabolic syndrome is a condition which causes biochemical changes in body making person prone to different kinds of diseases. These include life threatening diseases like myocardial infarction, stroke, etc., and lifelong diseases like diabetes mellitus, obesity, hypertension and their related complications. In the present study, common co-morbidities associated with Metabolic syndrome found were fungal infection, frozen shoulder, stroke, cataract and myocardial infarction (Table 6).

    Table 6. Co-morbidities associated with metabolic syndrome
    Co-Morbidity Metabolic Syndrome
    Yes No Total
    No (%) No (%) No (%)
    Fungal infection 21 (75.00) 7 (25.00) 28(100)
    Frozen Shoulder 16 (76.19) 5 (23.81) 21(100)
    Cataract 12 (63.16) 7 (36.84) 19(100)
    Myocardial Infarction 10 (62.5) 6 (37.50) 16(100)
    Stroke 3 (75.00) 1 (25.00) 4 (100)

    Discussion

    The prevalence found in our study was lower than that reported by Mishra et al (30%)6 and Sarkar S et al (30%)7, while it was higher than that reported by Gang Hu et al (15%)8, Gupta et al9 (13%) and Kamble P et al (17.3%)10. The finding that prevalence of Metabolic syndrome was higher in females as compared to males, is similar to many other previous studies.10, 11, 12, 13, 14 However some authors found contradictory results, reporting a higher prevalence among men.15, 16, 17

    In present study, Metabolic syndrome was found to be associated with advanced age. These findings were similar to Ford et al12 who reported prevalence of 42.0% for participants aged 60-69 years and 43.5% in 70 years and above.Similarly Bjorn Hildrum et al18concluded that the prevalence of Metabolic syndrome increased with age affecting less than 10% people in their 20s and 40% of people in their 60s. Other researchers19, 20, 21 have reported similar findings.

    In the present study maximum 50% widow and separated had metabolic syndrome. 66 (18.49%) married study subjects were having metabolic syndrome and 1 (7.69%) unmarried subjects have metabolic syndrome. These findings were similar to Troxel WM et al22who reported divorced (OR= 2.47; 95% CI=1.02-5.97), and widowed (OR=5.82; 95% CI=1.88-18.03) women were significantly more likely to have the Metabolic syndrome, but contradictory toBhanushali et al23 who reported single women had significantly lower prevalence of Metabolic syndrome compare with married women (OR= 0.43, 95% CI=0.43-0.99). HoweverPark et al24 reported that prevalence of Metabolic syndrome was not statistically significant in divorced or widowed men and women compared with married men and women (OR= 0.82, 95% CI= 0.57-1.17 and OR=1.03, 95% CI=0.84-1.26, respectively).

    The present study shows that,37.14 % subjects with Metabolic syndrome used to consume alcohol, and the association was statistically significant. This finding was similar to some studies25,26 while contradictory to others27, 28, 29.

    Present study found that 37.68 % study subjects with Metabolic syndrome were smokers and 16.92% were non-smoker. Smokers were more prone to develop Metabolic syndrome. This finding was similar to previous studies. 30, 31, 32, 33, 34, 35HoweverBhanushali et al23found no association between smoking and prevalence of Metabolic syndrome in African-American men and women.

    We found that vigorous physical activity was protective against metabolic syndrome. Similar finding has been reported in earlier studies. 36, 37, 38, 39, 40, 41, 42.

    In the presentmost common co-morbidity associated with Metabolic syndrome was frozen shoulder followed by stroke, cataract and myocardial infarction.

    Isomma et al43 in a Botnia Studyreported, in patient with Metabolic syndrome relative risk of CAD was 2.96 (CI 95% 2.36 to 3.72; P<0.0001) and cardiovascular mortality was significantly increased to 12% compared to 2% in subjects without Metabolic syndrome.Lakka et al44 in another Finnish study, found that all cause mortality associated with the Metabolic syndrome increased 1.9 fold and CVD mortality 2.6 fold.Sattar N et al45 reported Metabolic syndrome was associated with a 3.7 fold increase in coronary artery disease risk and 24.5 fold increase in incident diabetes compared to men without Metabolic syndrome,The Framingham Offspring Study46 reported the risk of CHD increased 2.4 fold for men and 5.9 for women, whileBonora et al47in the Verona Diabetes Complication Study found 92.3% of the population with CVDs to have Metabolic syndrome according to World Health Organization criteria.

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