Gene regulation is the molecular control of when, where, and how much a gene is expressed, coordinating the genome's output to meet the demands of development, homeostasis, and adaptation. It operates across multiple layers: transcriptional control by transcription factors binding regulatory elements—including the m…
Gene regulation is the molecular control of when, where, and how much a gene is expressed, coordinating the genome's output to meet the demands of development, homeostasis, and adaptation. It operates across multiple layers: transcriptional control by transcription factors binding regulatory elements—including the modulation of binding by regulatory single-nucleotide polymorphisms (rSNPs), as analyzed computationally for EPAS1 and STAT4; epigenetic mechanisms such as DNA methylation and histone modification; and post-transcriptional and post-translational regulation. Non-coding RNAs, including circular RNAs implicated in Alzheimer's disease, add further regulatory specificity, while protein regulators such as optineurin (FIP-2) govern downstream chemokine and kinase expression. These mechanisms shape disease processes and physiological states, illustrated by glucocorticoid receptor–mediated regulation of RNF43 in colorectal cancer, epigenetic control of brain-derived neurotrophic factor expression in chronic pain, and the influence of nutrition and dietary exposures on epigenetic programming. Regulatory variation is also examined through disease-associated polymorphisms such as TREM2 and MS4A6A and through bioinformatic analysis of coronary-disease loci, while evolutionary conservation of developmental regulators—exemplified by Hox genes in brain development—connects regulation to body-plan and lineage divergence. Molecular biomarkers further link regulatory states to function, as in probiotic anti-inflammatory activity. The journal publishes peer-reviewed research on transcription-factor and regulatory-SNP analysis, epigenetic regulation, and non-coding-RNA mechanisms.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 57 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Gene Regulation, linking to each citing work.