Research Topic · Peer-Reviewed

Plasma Proteomics

Plasma proteomics is the large-scale analysis of the proteins present in blood plasma, aiming to identify, quantify, and compare protein abundances across health and disease. Because plasma perfuses every tissue, it accumulates secreted, shed, and leaked proteins from across the body, making it an attractive but tec…

Curated from this journal's research 📚 11 peer-reviewed articles cited Cited 41× across the literature 🔖 ISSN 2326-0793 🗓 Reviewed July 2026

Overview

Plasma proteomics is the large-scale analysis of the proteins present in blood plasma, aiming to identify, quantify, and compare protein abundances across health and disease. Because plasma perfuses every tissue, it accumulates secreted, shed, and leaked proteins from across the body, making it an attractive but technically demanding sample for discovering disease markers and monitoring treatment response. The plasma proteome spans an extraordinarily wide dynamic range: a handful of highly abundant proteins such as albumin and immunoglobulins dominate by mass, while many clinically informative proteins occur at far lower concentrations. Consequently, workflows often combine depletion or enrichment steps with mass spectrometry-based discovery and quantification, including targeted and quantitative labeling approaches that improve reproducibility. Investigators relate circulating protein levels to physiological and pathological processes, for example linking soluble markers and their genetic modifiers to organ-specific disease, as in studies of plasma proteins associated with liver injury and neuroinflammation. Plasma proteomics intersects with bioinformatics resources that annotate the human proteome and support disease diagnosis. Key challenges include controlling pre-analytical variation, distinguishing true biological signal from technical noise, and validating candidate markers in independent cohorts before any clinical interpretation is warranted.

Research published in this journal

11 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2013

Quantitative Proteomics Using 15N SILAC Mouse

I. Chen EmilyCorresponding author
Stony Brook University, Proteomics Center, School Of Medicine, NY
Proteomics and Genomics Research Cited by 4 doi:10.14302/issn.2326-0793.jpgr-13-252

How this research is being cited

The 11 articles above have been cited 41 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Plasma Proteomics, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Proteomics and Genomics Research (ISSN 2326-0793).

Journal editorial board
Sutopa Dwivedi · United States Liuyang Wang · United States Juan Sainz · Spain

This page summarises published research for orientation; it is not medical or professional advice.